Cell mediated immune response to shope fibroma virus induced tumors in adult rabbits scott cb holdbrook r sell s the parameters of cell mediated immune responses of adult rabbits infected with shope fibroma virus sfv were characterized by measurement of the size of local draining nodes number of cells per lymph node mitogen responses of . Cytotoxic antibody response to tumors induced in adult and newborn rabbits by fibroma virus infect immun 1972 oct 6 4591 599 pmc free article tompkins wa walker dl hinze hc cellular deoxyribonucleic acid synthesis and loss of contact inhibition in irradiated and contact inhibited cell cultures infected with fibroma virus j virol. Summary in adult domestic rabbits inoculated with shope fibroma virus tumors began to regress about the 9th day well defined delayed type hypersensitivity reactions following intradermal challenge with virus antigen developed on the 5th day but circulating antibody was not demonstrable before the 7th day. Rabbits infected with a malignant variant of shope fibroma virus have depressed t cell activity and are susceptible to severe pasteurellosis but b cell function is depressed as well corbeil et al 1983 in mice cell mediated immunity seems to have a minor role since immune lymphocytes do not protect non immune recipients collins 1977. Tumors induced in rabbits by shope fibroma virus offer a system in which antibody and cell mediated immunity canbe evaluated under con ditions of progressive tumor growth and tumor regression without manipulation of the immune responses of the host intradermal inoculation of adult rabbitswithfibromavirus resultsintumors which grow for 9 to 11
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