Advanced drug delivery els evier reviews advanced drug delivery reviews 18 1996 295 301 the role of percutaneous penetration enhancers roderick b walker eric w smith school of pharmaceutical sciences rhodes university grahamstown south africa accepted 7 july 1995 abstract it is clear that scientists are now only beginning to comprehend the complexity of transdermal drug delivery. Library of congress cataloging in publication data percutaneous penetration enhancers i edited by eric w smith howard i maibach p em includes bibliographical references and index. Percutaneous penetration enhancers an overview thong hy1 zhai h maibach hi author information 1department of dermatology school of medicine university of california san francisco ca 94143 0989 usa transdermal drug delivery is the controlled release of drugs through the skin to obtain therapeutic levels systematically. Terpenes the naturally occurring volatile oils appear to be clinically acceptable penetration enhancers as indicated by high percutaneous enhancement ability reversible effect on the lipids of sc minimal percutaneous irritancy at low concentration 1 5 and good evidence of freedom from toxicity. Determination of drug penetration is covered in the final volume with a focus especially on mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration this edition of percutaneous penetration enhancers will be an invaluable resource for researchers pharmaceutical scientists practitioners and
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