1 introduction 11 aim and objectives the european association of urology eau non muscle invasive bladder cancer nmibc guidelines panel has compiled these clinical guidelines to provide urologists with evidence based information and recommendations for the management of upper urinary tract urothelial carcinoma utuc. Introduction upper urinary tract urothelial carcinoma utuc comprises approximately 10 of renal neoplasms and around 5 of urothelial carcinomas oosterlinck et al 2004 munoz and ellison 2000minimally invasive organ sparing endoscopic procedures have shown favourable survival data in select patients with small low grade tumours. Urothelial tumors often come back in new places in the urinary tract even if the initial growth was on the surface of the urinary tract new tumors develop lower in the ureter or the bladder in about 30 out of every 100 patients who have had upper tract tumors removed. Upper tract urothelial carcinomas utucs consist of 5 10 of all urothelial carcinomas the rest being urothelial carcinomas of the bladder ucb there is increasing evidence to show that utuc is a distinct disease entity from ucb based on phenotypical and genotypical genetic and epigenetic differences this may account for why the natural history of utuc is different from that of ucb . Context the european association of urology eau guidelines panel on upper urinary tract urothelial carcinoma utuc has prepared updated guidelines to aid clinicians in the current evidence based management of utuc and to incorporate recommendations into clinical practice
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